Human Growth Hormone – HGH Therapy

Growth hormone is a hormone produced by the pituitary gland and is one of the key regulators of human growth and development. The normal concentration of growth hormone in the blood is especially important for children from birth to puberty since during this period it promotes proper bone growth. The hormone is usually secreted into the blood in waves during the day with a peak concentration, usually at night. Excessive synthesis of the hormone contributes to excessive elongation of bones and continued growth even after puberty, which can lead to gigantism. In adults, growth hormone is less active but continues to play a corresponding role in the regulation of bone density, metabolism of fatty acids, maintenance of muscle mass.

To diagnose growth hormone abnormalities, a test for its suppression and stimulation is performed. Spontaneous measurement of its concentration is not used in clinical practice, since it is released in waves during the day. A blood test for somatotropin is not recommended for a general examination of the body. In most cases, it is prescribed for suspicions of violations that are associated with its production and after receiving results for other hormones or to help in the study of the function of the pituitary gland.

  • Preparation for research
  • exclude fatty foods from the diet 24 hours before the study
  • do not eat before donating blood for 12 hours
  • completely exclude taking medications before the study in 24 hours
  • refuse physical exertion and avoid emotional overstrain for 24 hours before the analysis
  • Indications for research

Diagnosis of FH abnormalities often includes a stimulation and suppression test which are used to assess pituitary function and changes in growth hormone levels.

A stimulation test helps diagnose growth hormone deficiency and hypopituitarism. To do this, the patient takes blood from a vein after 10-12 hours of abstinence from food, then, under medical supervision, a solution of insulin or arginine is injected intravenously. Next, blood samples are collected at regular intervals, at each of which the content of growth hormone is detected to determine whether insulin (or arginine) affects the pituitary gland, producing the expected hormone level.

 The suppression test helps diagnose excess hormone and, along with other blood tests and scintigraphy, identify and localize pituitary tumors. if the pituitary gland is sufficiently suppressed by the dose of glucose taken.


Gender Reference Values

Male 0-03 ng/ml Female 0-08 ng/ml Great care should be taken when interpreting STH test results. The level of hormone secretion by the pituitary gland constantly varies so in order to obtain objective indicators it is necessary to measure it several times and, as a result, take the average result. It is important not to be mistaken by mistaking daily fluctuations in the hormone levels for an anomaly.

Growth hormone levels are elevated in the morning and after exercise. It is necessary to compare the indicators of growth hormone with the data of the analysis for the insulin-like factor.

Results may be influenced by

The results of the test for growth hormone depend on several factors. First, these are drugs that increase (amphetamines, arginine, dopamine, estrogens, glucagon, histamine, insulin, levodopa, methyldopa and nicotinic acid) and lower (corticoids and phenothiazines) the level of growth hormone. Secondly, an examination with the use of radioactive substances less than a week before the analysis. Occasionally, symptoms of growth hormone deficiency can also be observed at normal or even elevated levels, this is due to hereditary resistance (resistance) to growth hormone. In this case, its level is increased, while the level of insulin-like factors on the contrary is lowered.

Appointed in conjunction with

  • Glucose tolerance test
  • Thyroid-stimulating hormone (TSH)
  • Plasma glucose
  • Prolactin

Final Words

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